Novel Arg128Ala variant in Catechol‐O‐methyltransferase gene influence persistent pain.

Autor: Dharaniprasad, Goduguchintha, Samantaray, Aloka, Srikanth, Lokanathan, Hanumantha Rao, Mangu, Chandra, Abha, Sarma, Potukuchi Venktata Gurunadha Krishna
Předmět:
Zdroj: Clinical Genetics; Feb2020, Vol. 97 Issue 2, p378-380, 3p, 1 Diagram
Abstrakt: The COMT gene locus is rich with single nucleotide polymorphisms (SNPs), leading to several alleles of which associated with chronic pain and pain-related phenotypes. There are some evidences of COMT gene polymorphisms, which affect COMT enzyme activity, and may adversely affects patient's ability to cope with pain.[1] Lane L1-L7 PCR amplified products of 220 bp of exon 4 of COMT gene from chronic post-surgical pain (CPSP) patients. [Extracted from the article]
Databáze: Complementary Index