| Autor: |
Митева, Мария Ж., Орбецова, Мария М., Нончев, Боян Ив., Давчева, Деляна М. |
| Zdroj: |
Endokrinologiâ; 2019, Vol. 24 Issue 3, p126-136, 11p |
| Abstrakt: |
The molecular mechanisms of actions of thyroid hormones (TH) on the skeleton are complex and only partially understood, occurring in both a direct and indirect manner. Тhe interaction of different thyroid receptors (TR) isoforms mediates the effects of TH on bone tissue. TH play a fundamental role in endochondral ossification, in skeletal development and growth and in the maintenance of bone mass. However, recent studies have provided evidence that TSH acts as a direct regulator of bone remodelling and TSH has been shown to activate osteoblast differentiation and inhibit bone resorption. The Wingless-type MMTV integration site (Wnt) pathway has emerged as a crucial regulator of bone formation and regeneration and Wnt signaling has been implicated in thyroid hormone-associated bone loss. The regulation of the Wnt signaling pathway, in particular its inhibitors Dickkopf 1 and sclerostin, in thyroid hormone induced bone disease has been recently evaluated. We present here a review of the action of TH on bone and of the impact of thyroid disorders on the skeleton with the focus on the molecular interactions between TH and skeletal cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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