Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome.

Autor: Bittar, Luis Fernando, Silva, Letícia Queiroz da, Orsi, Fernanda Loureiro de Andrade, Zapponi, Kiara Cristina Senger, Mazetto, Bruna de Moraes, Paula, Erich Vinícius de, Montalvão, Silmara Aparecida de Lima, Annichino-Bizzacchi, Joyce Maria
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Zdroj: PLoS ONE; 1/16/2020, Vol. 15 Issue 1, p1-14, 14p
Abstrakt: Introduction: Post-thrombotic syndrome (PTS) is a limiting long-term complication present in 20–50% of patients with deep venous thrombosis (DVT) of the lower limbs. A panel of biomarkers with potential relevance to enhance knowledge on the pathophysiology of PTS was investigated. Methods: This case-control study included 93 patients with DVT in the lower limbs, 31 with severe PTS (cases) and 62 with mild/no PTS (controls), over 24 months after an acute episode. Thirty-one healthy individuals (HI) with no history of DVT were included as a reference to the population. FVIII activity, D-dimer, inflammatory cytokines, endothelial dysfunction markers, matrix metalloproteinases, and their inhibitors, tissue remodeling and growth factor levels were evaluated. The classification of PTS was, by the Villalta scale. Results: Patients with severe PTS showed elevated levels of CRP, sICAM-1, sE-selectin, and decreased MMP-9 and MCP-1 levels when compared to patients with mild/no PTS. Moreover, DVT patients presented higher levels of FVIII and D-dimer when compared to HI. Conclusions: DVT patients present an inflammatory status, endothelial dysfunction and altered proteolysis MMPs activity, even a long time after the acute thrombotic episode, which is more significant in severe PTS. These results suggest a possible role of these mediators in the maintenance and worsening of PTS severity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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