EFFECT OF HESPERIDIN AND CIPROFLOXACIN ON THE FUNCTION AND HISTOLOGICAL STRUCTURE OF KIDNEY IN LOCAL MALE RABBITS.

Autor: Khudhiar, Auday Suliaman, AL-Khamas, Ahlam J. H., Hadi, Suhad Jameel, Murad, Manal Muhi, Faris, Jawad Kadhim, Kadhim albawi, Firas Hussain, Zballa Almermdhy, HayderAbd Al Emeer
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Zdroj: Biochemical & Cellular Archives; Oct2019, Vol. 19 Issue 2, p4279-4283, 5p
Abstrakt: The study was conducted to investigate the effect of use Hesperidin and Ciprofloxacinon the function of kidney through measurement of level of Creatinine (CR), Blood urea nitrogen (BUN) and Malonaldehyde enzyme (MAD) and histopathological changes in kidney of local male rabbits. (28) rabbits average (1378 -1380) gram were divided to 4 groups, every group (7) local male rabbits, group (1) the control gives only (2 ml) normal salineorally and group (2) gives only Hesperidin 100 mg/kg. b.w, group (3) gives only Ciprofloxacin 100 mg/kg.b.w. While group (4) gives Ciprofloxacin + Hesperidin 100 mg/Kg.b.w. respectively orally for 21 day. We conducted that the administration of Ciprofloxacin produce significance decrease ( P< 0.01) at100 mg/Kg.B.W. in thebody weight and there is significance increase (P< 0.01) in levels of Creatinine, Blood urea nitrogen and Malonaldehyde enzyme. Furthermore, there is a significant difference ( P< 0.01 ) in the effect of the combination of Hesperidin and Ciprofloxacin, but its significance was less than the effect of Ciprofloxacin alone. We concluded that the administration of Ciprofloxacin with Hesperidin reduces bad effects in body weight and renal function of local male rabbits. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index