| Abstrakt: |
This study was designed to assess upgraded role of hydrolysate proteins especially casein on hypercholesterolemia that induced by high cholesterol in adult female rats. Twenty-four adult female rats were randomly selected and equally divided into four groups as follows C, G1 and G2. They were treated orally daily for 56 days as follows, C:control group were given (1 ml) distilled water by gavage needle and G1: rats of this group were given (1g/Kg/B.W) cholesterol, G2:rats of this group received cholesterol (1g/Kg/B.W) with casein hydrolysate (1g/Kg/B.W). Fasting blood samples were collected by cardiac puncture technique at (56 day) of the experiment period for measuring the following parameters: Total cholesterol, Triglyceride, troponin, lactate dehydrogenase, creatine kinase and histopathology of heart and Aorta. Results observed a significant increase (p<0.05) in total cholesterol (TC), with significant (p<0.05) decrease in casein hydrolysate with high cholesterol group (G2) compared with high cholesterol group (G1). In addition results referred that triglyceride in (G2) decreased significantly (p<0.05) compared with (G1) group. However, results referred that cardiac markers decreased significantly (p<0.05) in casein hydrolysate with high cholesterol. Meanwhile, results showed that cholesterol effects significantly on cardiac cells by causing coagulative increase with fragmented myofibers and hemorrhage with hyper eosinophilic myofibers in (G1) group, compared with casein hydrolysate with high cholesterol (G2) that ameliorates this damaging effect. In conclusion, the results of this study documented that casein hydrolysate is a good hypocholesterolemic milk peptides that amend the mischievous effects of cholesterol in adult female rats [ABSTRACT FROM AUTHOR] |
