| Autor: |
Hamza, Abdulsatar S., AL-Timemi, Hameed A. K., Shabeeb, Zeyad A. |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2019, Vol. 19 Issue 2, p3395-3399, 5p |
| Abstrakt: |
Articular cartilage has a limited capacity to heal itself and the defects often result in the development of osteoarthritis. Current cartilage tissue engineering strategies seek to regenerate injured tissue by creating scaffolds that aim to mimic the unique structure and composition of native articular cartilage. The purpose of this study was to develop a three dimensional acellular cartilage matrix as a powder ACMP for cartilage substitution. Additionally, the prepared scaffolds obtained from lyophilization was evaluated in vitro, by histological, SEM and XRD analysis, SEM showed that the ACMP had a sponge-like structure of high porosity. XRD showed, the broad peaks with relatively low intensity at 2θ = 7.9°, 20.3° and 37.7° is related to presence of semi-crystalline or amorphous organic materials, which are chondroitin sulfate(CS), Collagen Type 1(Col1) and type 2(Col2), hyaluronic Acid(HA) and proteoglycan (PG). This study provides a technique to produce acellular ECM derived from articular bovine cartilage which may serve as a xenogenic scaffold for cartilage tissue regeneration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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