| Autor: |
Chapman, Christopher A. R., Cuttaz, Estelle A., Goding, Josef A., Green, Rylie A. |
| Předmět: |
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| Zdroj: |
Applied Physics Letters; 1/6/2020, Vol. 116 Issue 1, p1-5, 5p, 1 Diagram, 1 Graph |
| Abstrakt: |
Localized and actively controlled delivery of drugs presents an opportunity for improving bioavailability, therapeutic efficacy, and long-term treatment of injury or disease. Conductive polymer (CP) based systems present a unique opportunity for using inherent electrochemical and actuating properties to ensure that drugs are delivered or retained using charge controlled mechanisms. A number of CP formats have been explored spanning CP films, composites of CPs with polymeric carriers, and organic electronic ion pumps (OEIPs). Each of these designs can be used to deliver drugs with ionic properties that take advantage of the doping and dedoping characteristics of CPs during electrical pulsing or cycling. However, CP composites that use actuation and OEIPs are emerging technologies that can better address the need for the delivery of a wide range of drugs with varying net charge properties. These systems also allow a high drug loading profile, and with an appropriate configuration, they can use additional electrodes to drive drugs into the tissues. There are also innovative opportunities in the delivery of multiple drug types with varying charge properties that can be individually addressed. The future of CP based drug delivery systems will be strongly influenced by translational challenges including the need for regulatory approvals prior to the use of these novel material platforms in the clinic. Multidisciplinary collaboration will be critical to driving technology development and creating a new paradigm in personalized bioelectronic delivery of therapeutics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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