| Autor: |
Khalil, Ahmad M., Alsheikh Hussien, Lulu H., Alghadi, Ahmad Y., Alazab, Rami S., Alwuhoush, Ahmad Y., Al-Ghazo, Mohammad A., Aldaoud, Najla H. |
| Předmět: |
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| Zdroj: |
Jordan Journal of Biological Sciences; 2019, Vol. 12 Issue 5, p603-608, 6p |
| Abstrakt: |
The X-box binding protein-1 (XBP1), a critical gene in the endoplasmic reticulum stress response, has been linked to many cancers in several studies. Recent studies indicate that the upregulation of XBP1 promotes cell proliferation and invasion of prostate cancer (PC). This research is aimed at the measurement of the frequencies of Exon 1 and -116 C/G promoter polymorphism on the XBP1 gene as well as the investigation of this polymorphism as a predisposing genetic marker to assess possible strategies for screening families at the risk of developing PC. Blood samples of seventy patients with PC and seventy healthy individuals were evaluated using TaqMan genotyping technique and direct DNA sequencing analysis. Overall, the sequencing of exon1 of the XBP1 showed that there was no mutation, neither in PC subjects nor in the control. Additionally, there was no significant statistical difference between the PC cases with -116C/G polymorphism of XBP1 and the control subjects in the genotype (P = 0.674) and allele frequencies (P = 0.436). The present study is the first report to discuss the risk factors associated with mutations in XBP1 in PC progression. The results suggest no significant relevance between -116C/G and exon 1 (rs5762809 and rs2228260), and PC susceptibility in the Jordanian population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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