| Autor: |
Majeed, Sarah N., Al-Essa, Nagham E., Ahmed, Najwa Sh. |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Oct2019, Vol. 10 Issue 10, p2113-2118, 5p |
| Abstrakt: |
Diabetes mellitus is one of the most common chronic diseases in nearly all countries, and continues to increase in numbers and significance. Various environmental and genetic factors interact and increase the risk of Type 2 diabetes mellitus and its complications. The study consist of 105 patients having Type 2 diabetes mellitus and 50 healthy controls, measured some biochemical parameters, genomic DNA extracted from whole blood, and C825T polymorphism was detected by polymerase chain reaction- Restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing of amplified product of GNB3 gene for studies group. The results of molecular analysis for GNB3 genetic polymorphism shows that the frequency of (CC) genotype in T2DM patients and controls group (5.7%; 4%) respectively and the (CT) genotype (65.7%; 86%) respectively, while the (TT) genotype frequency was (28.6%; 10%) respectively. So, There were significant differences in CT and TT genotype when compared T2DM patients to control group, but no significant in CC genotype. Furthermore the TT genotype nearly (3.6) fold increases the risk factor for T2DM. We also observed that the levels of fasting blood glucose and Triglyceride increased in individuals who have the CT and TT genotypes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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