| Autor: |
Alsaeedi, Intisar M., Abed, Sadeem S., Muhamad, Yasmeen H. |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Oct2019, Vol. 10 Issue 10, p975-982, 8p |
| Abstrakt: |
Batch and Flow injection analysis (FIA) spectrophotometric Method have been presented for determination of nifedipine (NIF)in pure and pharmaceutical forms. The Method were based on the diazotization coupling reaction of NIF with diazotized p-nitro aniline (DPNA)in the presence of alkaline medium. Red product was formed and measured at λmax509 nm. All optimum conditions were studied for each method. Linearity of NIF was observed for batch 20-100 µg.mL-1 and for FIA5-120 µg.mL-1 and the detection limits were 4.197, 1.326 µg.mL-1 for batch, FIA respectively. The method offered a good sensitivity, accuracy and precision; FIA was more convenient than batch method because of the wider linear range moreover, the sampling rate was 28 injections per hour but less reproducibility than batch method. A comparison study was carried out between the proposed and standard Method by calculating students' t-test and F-test indicated no significant differences between them, the suggested method could be utilized for pharmaceutical analysis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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