| Autor: |
Lin, Ching-Hung, Yap, Yoon Sim, Lee, Kyung-Hun, Im, Seock-Ah, Naito, Yoichi, Yeo, Winnie, Ueno, Takayuki, Kwong, Ava, Li, Huiping, Huang, Shu-Min, Leung, Roland, Han, Wonshik, Tan, Benita, Hu, Fu-Chang, Huang, Chiun-Sheng, Cheng, Ann-Lii, Lu, Yen-Shen, Group, The Asian Breast Cancer Cooperative, Asian Breast Cancer Cooperative Group |
| Předmět: |
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| Zdroj: |
JNCI: Journal of the National Cancer Institute; Dec2019, Vol. 111 Issue 12, p1298-1306, 9p, 1 Chart, 3 Graphs |
| Abstrakt: |
Background: The incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in East Asian women and women of predominantly European ancestry.Methods: We excerpted analytic data from six national cancer registries (979 675 cases) and eight hospitals (18 008 cases) in East Asian countries and/or regions and, for comparisons, from the US Surveillance, Epidemiology, and End Results program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided.Results: Unlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged 59 years and younger increased disproportionally over recent decades relative to rates in US contemporaries. For years 2010-2014, the estimated age-specific probability of estrogen receptor positivity increased with age in American patients, whereas that of triple-negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients; their probability of estrogen receptor positivity at age 40-49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI] = 1.36 to 1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI = 0.71 to 0.88, P < .001), whereas the probability of ER positivity at age 50-59 years was statistically significantly lower (OR = 0.88, 95% CI = 0.828 to 0.95, P < .001). Subgroup analyses of US Surveillance, Epidemiology, and End Results data showed similarly distinct patterns between East Asian American and white American patients.Conclusions: Contrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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