| Autor: |
Chekryshkina, L. A., Demin, A. M., Tumashov, A. A., Babikova, E. A., Slepova, N. V. |
| Předmět: |
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| Zdroj: |
Russian Journal of Organic Chemistry; Oct2019, Vol. 55 Issue 10, p1532-1538, 7p |
| Abstrakt: |
A procedure for the synthesis of 2-(diethylamino)-N-(2-methylphenyl)acetamide nitrate (monomecaine) exhibiting a pronounced antiarrhythmic activity has been optimized. A procedure for its identification and quality control of the drug substance by HPLC has been developed, and the limit of detection of o-toluidine impurity therein has been estimated at 0.02%. Procedures for HLPC and extraction-titration quantification of monomekain in the drug substance have been proposed and validated. The obtained relative standard deviation (RSD) indicates good specificity, linearity, and precision of the developed procedures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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