| Autor: |
Andreas, Nico, Weber, Franziska, Meininger, Isabel, Templin, Nicole, Gaestel, Matthias, Kamradt, Thomas, Drube, Sebastian |
| Předmět: |
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| Zdroj: |
European Journal of Immunology; Dec2019, Vol. 49 Issue 12, p2159-2171, 13p |
| Abstrakt: |
In mast cells, IL‐33 typically induces the activation of NF‐κB, which results in the production of cytokines such as IL‐6 and IL‐2. Here, we demonstrate that the IL‐33‐induced IL‐6 production in murine mast cells and the formation of RORγt+Tregs essentially depends on the MAPKAPs, MK2, and MK3 (MK2/3) downstream of MyD88. In contrast to this, the IL‐33‐induced and MyD88‐dependent IL‐2 production in mast cells contributes to the maintenance of Helios+Tregs. Thereby, the IL‐33‐induced IL‐2 response and, thus, the maintenance of Helios+Tregs are limited by an IL‐6‐mediated autocrine negative feedback stimulation acting on mast cells. Collectively, we present MK2/3 in IL‐33‐activated mast cells as a signaling node, which controls the dichotomy between RORγt+Treg and Helios+Treg in vitro. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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