γ‐Functionalization of α,β‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines.

Autor:	Sim, Jaeuk, Viji, Mayavan, Rhee, Jeongtae, Jo, Hyeju, Cho, Suk Joon, Park, Yunjeong, Seo, Seung‐Yong, Jung, Kwan‐Young, Lee, Heesoon, Jung, Jae‐Kyung
Předmět:	NITRILES HORNER-Emmons reaction KETONES CYANIDES
Zdroj:	Advanced Synthesis & Catalysis; 12/3/2019, Vol. 361 Issue 23, p5458-5465, 8p
Abstrakt:	This report describes the synthesis of 4‐aryl‐2‐halopyridines via γ‐functionalization of α,β‐unsaturated nitriles, which were obtained by the HWE reaction with the corresponding ketones. The key features of our methods involve a conjugated γ‐enamine formation of α,β‐unsaturated nitrile (enamino nitrile), followed by consecutive intramolecular cyclization, resulting in heteroaromatic compounds like 2‐halopyridines, α‐pyrone, etc. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.