| Autor: |
Jung, Soonjae, Anusha, J. R., Park, Seungil, Yu, Kook Hyun, Raj, C. Justin, Kim, Byung Chul |
| Předmět: |
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| Zdroj: |
New Journal of Chemistry; 12/21/2019, Vol. 43 Issue 47, p18657-18662, 6p |
| Abstrakt: |
A series of benzopyran derivatives were synthesised, and the target product, 6-amino-2-methyl-2-phenethyl-2H-benzopyran (compound 4), was labeled with radioactive 64Cu (64Cu-6). Compound 4 induced significant apoptosis and suppressed cell proliferation of SK-BR-3 by inhibiting overexpression of the HER2 protein. Furthermore, the 64Cu-6 with significant stability and lipophilicity showed high cellular uptake and cytotoxicity in SK-BR-3, suggesting its promise for dual applications, namely as a diagnostic imaging probe in positron emission tomography (PET) and in cancer treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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