| Autor: |
Van Gool, C. J. A. W., Thijs, C., Dagnelie, P. C., Henquet, C. J. M., van Houwelingen, A. C., Schrander, J., Menheere, P. P. C. A., van den Brandt, P. A. |
| Předmět: |
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| Zdroj: |
Allergy; Sep2004, Vol. 59 Issue 9, p961-968, 8p |
| Abstrakt: |
The hygiene hypothesis suggests that the protective ‘siblings effect’ against atopic diseases such as atopic dermatitis, allergic asthma and hay fever is a result of recurrent infections during early childhood. A recent study and review have indicated that this protective effect may already arise in utero. Lower n-3 essential fatty acid (EFA) status is associated with increased parity, and EFA status has also been related to atopy. The present study confirms the negative association between parity and neonatal immunoglobulin E (IgE) levels and further unravel the role of perinatal EFA status. In a prospective cohort study in 184 atopic mothers and their neonates, we simultaneously measured serum total IgE and EFA levels in plasma phospholipids, both in the mother at 34–36 weeks of gestation and in the neonate at the age of 1 week. Linear regression analysis was used to estimate the effect of parity on maternal and neonatal IgE and EFA status, and the independent effects of parity and EFA status on IgE, controlling for confounding factors such as maternal age and birth season. Parity was associated with lower neonatal IgE level ( P < 0.01), as well as with lower docosahexanoic acid (DHA, 22:6n-3) status of the mother ( P = 0.01) but not of the neonate ( P > 0.69). In the multivariate analysis, higher parity, higher maternal IgE, lower maternal age and birth in the first 3 months of the year were independently associated with neonatal IgE level. No association was detected between maternal or neonatal EFA status and neonatal IgE. As neonatal total serum IgE is predictive of later atopy, our results support the hypothesis that the sibling effect in atopy is already being programmed in utero. Our data also confirm earlier findings that DHA status is lower in multiparous women, but this did not confound the relation between parity and neonatal IgE. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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