| Autor: |
Huang, Xinqiong, Qian, Yujie, Wu, Hainan, Xie, Xiaoxue, Zhou, Qin, Wang, Ying, Kuang, Weilu, Shen, Lin, Li, Kai, Su, Juan, Shen, Liangfang, Chen, Xiang |
| Předmět: |
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| Zdroj: |
Journal of Histochemistry & Cytochemistry; Feb2015, Vol. 63 Issue 2, p88-98, 11p |
| Abstrakt: |
Radiotherapy is the first-line treatment for all stages of cervical cancer, whether it is used for radical or palliative therapy. However, radioresistance of cervical cancer remains a major therapeutic problem. Consequently, we explored if E-cadherin (a marker of epithelial-mesenchymal transition) and osteopontin could predict radioresistance in patients with locally advanced cervical squamous cell carcinoma (LACSCC). Patients were retrospectively reviewed and 111 patients divided into two groups (radiation-resistant and radiation-sensitive groups) according to progression-free survival (PFS). In pretreated paraffin-embedded tissues, we evaluated E-cadherin and osteopontin expression using immunohistochemical staining. The percentage of patients with high osteopontin but low E-cadherin expression in the radiation-resistant group was significantly higher than those in the radiation-sensitive group (p <0.001). These patients also had a lower 5-year PFS rate (p <0.001). Our research suggests that high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with LACSCC ([Hazard ratios (95% CI) 6.766 (2.940, 15.572)], p <0.001). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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