| Abstrakt: |
In 1972, Toker reported five cases of a previously unrecognized primary tumor of the skin with peculiar histologic features. Because of striking ultrastructural similarities to normal Merkel cells (MC), they proposed that the trabecular carcinoma could originate from MC; however, no definite histogenetic relationship between normal MC and the carcinoma cell has ever been documented. The stem cells or the extraepithelial neuroendocrine cells, however, still need to be either located or even described. |
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