| Autor: |
French, Nigel P., Ji Zhang, Carter, Glen P., Midwinter, Anne C., Biggs, Patrick J., Dyet, Kristin, Gilpin, Brent J., Ingle, Danielle J., Mulqueen, Kerry, Rogers, Lynn E., Wilkinson, David A., Greening, Sabrina S., Muellner, Petra, Fayaz, Ahmed, Williamson, Deborah A., Zhang, Ji |
| Předmět: |
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| Zdroj: |
Emerging Infectious Diseases; Dec2019, Vol. 25 Issue 12, p2226-2234, 9p |
| Abstrakt: |
In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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