| Autor: |
Sevostianova, V. V., Mironov, A. V., Krivkina, E. O., Khanova, M. V., Velikanova, E. A., Matveeva, V. G., Glushkova, T. V., Antonova, L. V., Barbarash, L. S. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2019, Vol. 2167 Issue 1, p020321-1-020321-5, 5p, 2 Diagrams, 1 Chart, 1 Graph |
| Abstrakt: |
Carotid endarterectomy using vascular patches is associated with a large number of complications, thereby necessitating the development of novel biocompatible materials suitable for the reconstruction of the vascular wall. A promising approach to overcome this problem is to use a combination of a biodegradable polymer and bioactive molecules that stimulate the regeneration of vascular tissue. In this study, porous vascular patches were made from polycaprolactone (PCL) with incorporated vascular endothelial growth factor (VEGF) molecules using emulsion electrospinning. Their morphology, mechanical properties, and ability to regenerate in vivo were assessed and compared with original PCL patches and commercially available xenopericardial patches. PCL/VEGF patches had a highly porous structure and strength similar to that of the native artery. After the implantation into the rat aortic wall, these patches were populated faster by cells with the formation of the inner endothelial layer and the extracellular matrix compared to xenopericardial and original PCL patches. PCL/VEGF patches maintained their integrity and were less susceptible to calcification in the long-term period. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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