| Autor: |
Rubtsov, K. V., Kondranova, A. M., Lozhkomoev, A. S., Kazantsev, S. O., Mamonova, E. V., Gavrilova, L. O., Sadovoy, M. A. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2019, Vol. 2167 Issue 1, p020298-1-020298-4, 4p, 1 Diagram, 1 Chart, 2 Graphs |
| Abstrakt: |
In the present study, novel nanoparticle-hydrogel composites have been synthesized as a potential hemostatic wound-healing agent. Poly(sodium acrylate) has been cross-linked by aluminum ions, forming physical hydrogel, which was used as a matrix, while nanoscale boehmite (γ-AlOOH) and Fe2O3 were used as fillers. A new approach to hydrogel synthesis has been proposed. This technique involves oxidation of aluminum nanoparticles suspended in poly(sodium acrylate) concentrated solution, thus, generating aluminum ions, which serve as a cross-linking agent, forming hydrogel network. In order to obtain nanoparticle-hydrogel composites, nanoscale fillers were added to polymer solution prior to hydrogel formation. MTT-assay, performed for analyzing the cytotoxic effects of all synthesized nanocomposites, revealed its non-toxicity at the concentrations 0.1 – 0.00625 mg/ml. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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