| Autor: |
Horax, Sherly, Achmad, Harun, K., Mirdawati |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Aug2019, Vol. 10 Issue 8, p1868-1872, 5p |
| Abstrakt: |
Background: Wounds are lost or damaged body tissue integrity due to trauma experienced such as sharp objects trauma. The initial occurrence of the wound will trigger the body’s response to inflammation which is a complex biological response and the body’s immune system to dangerous stimuli. Clinically the inflammatory phase is characterized by symptoms around the tissue such as increased heat, redness (rubor), pain (dolor), swelling (tumor), and loss of function. Excessive trade processes can be suppressed by giving anti-inflammatory ingredients such as propolis. Propolis is a natural material from bees that has anti-inflammatory properties that can be an alternative ingredient in suppressing inflammation that occurs to reduce the clinical symptoms that appear. Objective: To know the potential for topical administration of propolis to the migration of macrophages to wounds in mice. Method: This study was a pure laboratory experiment with a post-test only control group design. The subjects of this study were 24 mice divided into 12 treatment groups which were given topical propolis and a control group of 12 who were not given propolis. An incision with a wound of 2 mm and a length of 15 mm was carried out on the back of the mice then the wound was smeared with 80% propolis extract twice a day for the treatment group. Three mice were sacrificed for each observation day, namely days 1, 3, 5, 7 and then made tissue preparations, then macrophages were observed using a microscope. Results: There were significant differences between the treatment and control groups using the Mann Whitney test statistical analysis. Conclusion: There is the influence of topical propolis administration in mice wounds against macrophage cell migration as an anti-inflammatory effect of propolis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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