| Autor: |
Sayah, Mohammed Abdulkadhim, Mezher, Musa Nima |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Aug2019, Vol. 10 Issue 8, p1169-1173, 5p |
| Abstrakt: |
Background: Coxsackievirus B (CVB) which belong to enterovirus, has been widely implicated into triggering of Type 1 Diabetes Mellitus disease through many suggested mechanisms. This study was designed to investigating and understanding the relationship between CVB infection and inducing Type 1 Diabetes disease via estimation of many parameters within patients’ serum like Anti-Glutamic acid decarboxylase autoantibody and proinflammatory cytokines (TNF- and IL-6) that induced upon CVB infection. Patients and Method: A case-control study included 58 of diabetes mellitus type 1 patients and 30 normal control. All patients were diagnosed according to clinical history and the patients and control subjected to estimation of (Anti-CVB IgG, Anti-Gad, TNF- α and IL-6) within serum via ELISA assay. Results: The frequencies of (Anti-Gad, TNF- α and IL-6) showed higher levels among T1D patients in comparison to control and these parameters revealed significant association with high level of Anti-CVB IgG among patients . Conclusion: The high level of (Anti-Gad) and (TNF- α and IL-6) within CVB-T1D patients may indicated the possible role CVB viruses in the inducing autoimmunity disorder of T1D. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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