Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.

Autor:	Blot, Stijn, Antonelli, Massimo, Arvaniti, Kostoula, Blot, Koen, Creagh-Brown, Ben, de Lange, Dylan, De Waele, Jan, Deschepper, Mieke, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovestky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam
Předmět:	INTRA-abdominal infections INTRA-abdominal hypertension EPIDEMIOLOGY NOSOCOMIAL infections DRUG resistance in microorganisms COMMUNITY-acquired infections CRITICALLY ill CATASTROPHIC illness COMPARATIVE studies CAUSES of death EPIDEMIOLOGICAL research LONGITUDINAL method RESEARCH methodology MEDICAL cooperation RESEARCH SEPSIS EVALUATION research
Zdroj:	Intensive Care Medicine; Dec2019, Vol. 45 Issue 12, p1703-1717, 15p, 2 Diagrams, 6 Charts
Abstrakt:	Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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