| Autor: |
Gerstl, Lucia, Weinberger, Raphael, Heinen, Florian, Bonfert, Michaela V., Borggraefe, Ingo, Schroeder, A. Sebastian, Tacke, Moritz, Landgraf, Mirjam N., Vill, Katharina, Kurnik, Karin, Sorg, Anna-Lisa, Olivieri, Martin |
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| Zdroj: |
Journal of Neurology; Dec2019, Vol. 266 Issue 12, p2929-2941, 13p, 5 Charts, 3 Graphs |
| Abstrakt: |
Objective: Childhood arterial ischaemic stroke (AIS) is rare, but causes significant morbidity and mortality. We aimed to investigate incidence, age-dependent clinical presentation, and risk factors and to discuss the medical care situation in Germany. Methods: This prospective epidemiological study was conducted via ESPED (Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland), a hospital-based German nation-wide surveillance unit for rare pediatric diseases. Children aged 28 days–18 years with first AIS between January 2015 and December 2017 were included. Results: In the 3-year period, 164 children were reported. Incidence showed peaks in infants, children < 2 years of age, and adolescents (12–18 years), with a significant male predominance observed in adolescents only. Independent of age, most children (91%) presented with focal symptoms, particularly with acute hemiparesis. The occurrence of seizures in infants (57%) and more nonspecific symptoms in school-children and adolescents (54%) is considered noteworthy. Prothrombotic states (34%), cardiac disorders (29%), and arteriopathies (19%) were the most frequently identified risk factors. The majority of children (72/131, thus 55%) were discharged home after acute care phase. At time of discharge, most common neurological symptoms were hemiparesis (42%), facial palsy (15%), and speech disturbance (12%). Conclusion: This study provides population-based data of childhood AIS which may be useful for further research. The improvement of acute stroke management is needed for children, but also the standardization of post-stroke care in the outpatient setting has to be structured. Considering the higher stroke incidence in (male) adolescents, it is advisable to combine research activities in adolescents and young adults. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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