| Autor: |
Шентова, Р., Байчева, М., Хаджийски, П., Кофинова, Д., Пантелеева, Е., Янева, П. |
| Zdroj: |
Pediatria; 2019, Vol. 59 Issue 3, p19-22, 4p |
| Abstrakt: |
Background: Crohn’s disease (CD) is an idiopathic, chronic inflammatory disorder that can affect any part of the gastrointestinal tract from the mouth to the anus. Only 25% of pediatric CD patients present with the classic triad of abdominal pain, diarrhea and weight loss. Some children presenting with atypical or non-gastrointestinal symptoms may have delayed recognition and diagnosis. The aim of our study was to assess the clinical characteristics and the diagnostic delay in pediatric patients with CD. Material and methods: A single center observational retrospective study, including 40 children with CD treated in the Department of Gastroenterology and Hepatology, at the University Pediatric Hospital ”Prof. Ivan Mitev”, Sofia between March 2011 and December 2018. Results: 17 girls and 23 boys took part in the study. Median age at disease onset was 15 years (range 7‑17 years). The most common presenting symptom at the time of diagnosis was abdominal pain 40.0% (16/40), followed by diarrhea 27.5% (11/40). In 15.6% of the cases the disease debuted with an extraintestinal manifestation. Ileocolonic disease (L3) was seen in 62.5% (25/40), isolated terminal ileal disease (L1) in 17.5% (7/40) and isolated colonic disease (L2) in 20.0% (8/40) of our patients. Forty-five percent had involvement of the upper gastrointestinal tract. Most of the study participants 65.0% (26/40) had non-stricturing and non-penetrating disease (B1). Stricturing disease (B2) was observed in 15.0% (6/40) of them, penetrating disease (B3) in 10.0% (4/40) and stricturing and penetrating disease in 10.0% (4/40). Perianal disease was identified in 15.0% (6/40) of our CD patients and 15.0% (6/40) of them had growth failure. The median overall time from initial symptoms to diagnosis was 5 months (range 1‑72 months). Conclusion: Diagnostic delay in pediatric Crohn’s disease patients is well recognized and correlates with increased complications rate. Analyzing the heterogeneous clinical characteristics in our cohort of children with CD is key to establish appropriate measures to shorten this delay. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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