Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method.

Autor: Boquete, L., López-Guillén, E., Vilades, E., Miguel-Jiménez, J. M., Pablo, L. E., De Santiago, L., Ortiz del Castillo, M., Alonso-Rodríguez, M. C., Morla, E. M. Sánchez, López-Dorado, A., Garcia-Martin, E.
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Zdroj: PLoS ONE; 11/8/2019, Vol. 14 Issue 11, p1-12, 12p
Abstrakt: Purpose: To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS). Methods: We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F:M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor. Results: The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant. Conclusion: By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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