Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy.

Autor: Schneider, Lukas, Larocca, Michele, Wu, Wenyu, Babu, Vipin, Padrutt, Roxane, Slyshkina, Ekaterina, König, Christiane, Ferrari, Stefano, Spingler, Bernhard
Předmět:
Zdroj: Photochemical & Photobiological Sciences; Nov2019, Vol. 18 Issue 11, p2792-2803, 12p
Abstrakt: We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-(trans-Pt(NH3)2Cl)-tetra(3,4-pyrido)porphyrazine-zinc(II)](NO3)4 (4), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile (1). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc(II) (2), whereby the zinc(II) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-(trans-Pt(NH3)2Cl)-tetra(3,4-pyrido)porphyrazine](NO3)4 (5) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine (3). The final product 4 and the intermediates were characterized, the photochemical and photophysical properties were determined and the photocytotoxicities were investigated. We demonstrate that the platinated tetra-pyridinoporphyrazine 4 is a potential photosensitizer for photodynamic therapy (PDT). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: