Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft.
| Autor: | Chen, Yuling, Lu, Sai, Wu, Ying, Shen, Yuzhi, Zhao, Haibo, Ding, Shu, Feng, Xinwei, Sun, Li, Tao, Xiangjun, Li, Jinglian, Ma, Ruiying, Liu, Weiwei, Wu, Fangqin, Feng, Yadi |
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| Předmět: |
ANALYSIS of variance
BIOMARKERS BLOOD collection CONFIDENCE intervals CORONARY artery bypass DELIRIUM ENZYME-linked immunosorbent assay INTENSIVE care units INTERLEUKINS LONGITUDINAL method MULTIVARIATE analysis SCIENTIFIC observation POSTOPERATIVE period PSYCHOLOGICAL tests PSYCHOSES RESEARCH funding STATISTICS SURGICAL complications TIME LOGISTIC regression analysis DATA analysis REPEATED measures design RECEIVER operating characteristic curves DATA analysis software ODDS ratio |
| Zdroj: | American Journal of Critical Care; Nov2019, Vol. 28 Issue 6, p462-470, 9p, 1 Diagram, 3 Charts, 2 Graphs |
| Abstrakt: | Background Serum level of interleukin 6 (IL-6) is known to be associated with postoperative delirium. However, no consensus has emerged on the postoperative time point at which IL-6 level may predict postoperative delirium after coronary artery bypass graft surgery. Objectives To compare trends in IL-6 levels in patients with and without postoperative delirium and to examine the relationship between IL-6 levels at different times and postoperative delirium after coronary artery bypass graft. Methods A prospective cohort study of patients who underwent their first elective isolated coronary artery bypass graft between November 2013 and August 2015 at a cardiac intensive care unit in Beijing, China. Concentrations of IL-6 were measured before the operation and at the 6th, 12th, and 18th postoperative hours. Participants were assessed for postoperative delirium twice daily for 5 days. Univariate and multivariate logistic regression analyses were done to determine associations between IL-6 levels at different time points, postoperative changes in IL-6 levels, and the occurrence of postoperative delirium. Results Postoperative delirium was diagnosed in 85 of 266 patients (32%). Levels of IL-6 were significantly higher in patients with postoperative delirium than in patients without it at the 6th, 12th, and 18th postoperative hours (P =.03,.004, and.001, respectively). Change in IL-6 level (odds ratio, 2.97; 95% CI, 1.20-7.31; P =.02) and IL-6 level of 583 pg/mL or higher at the 18th postoperative hour (odds ratio, 5.20; 95% CI, 1.84-14.70; P =.002) were associated with higher incidence of postoperative delirium. Conclusion Interleukin 6 level (≥ 583 pg/mL) at the 18th postoperative hour may serve as a potent predictor of postoperative delirium in coronary artery bypass graft patients. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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