| Autor: |
Zhukov, Nikolay, Mareeva, Yulia, Konovalov, Dmitry, Druy, Alexander, Grachev, Nikolay, Litvinov, Dmitry |
| Předmět: |
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| Zdroj: |
JCO Precision Oncology; 11/4/2019, Vol. 3, p1-6, 6p |
| Abstrakt: |
Potentially Curative Targeted Therapy for Undifferentiated High-Grade Sarcoma Developing After Malignant Transformation of a BRAF V600E-Mutated Ameloblastic Fibroma Ameloblastic fibroma (AF) is a rare benign odontogenic tumor, consisting of odontogenic epithelium and mesenchymal tissues. Because the tumor was borderline resectable, the patient had experienced multiple recurrences, and malignant transformation of the tumor had been confirmed; aggressive soft tissue sarcoma-oriented chemotherapy aimed at tumor shrinkage was administered. Because of the high chance of recurrence and chemotherapy resistance of the tumor, we performed an extensive search for potential drug targets for noncytotoxic therapy and found a I BRAF i V600E mutation in the tumor, indicating the tumor could respond to anti-BRAF/MEK therapy. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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