| Autor: |
Lee, Yeongju, Im, Haeri, Das, Sanket, Oh, Misook, Lee, Ji Hoon, Ham, Sihyun, Lim, Hyun-Suk |
| Předmět: |
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| Zdroj: |
Chemical Communications; 11/14/2019, Vol. 55 Issue 88, p13311-13314, 4p |
| Abstrakt: |
Herein, we report a strategy for generating conformationally restricted α-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of α-helix mimetics. We demonstrate that the bridged α-helix mimetics have enhanced binding affinity and specificity to the target protein due to the restricted conformation as well as extra interaction of the bridge with the protein surface. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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