| Autor: |
Safavi, R., Lih, A., Kirkpatrick, S., Haller, S., Bailony, M. R. |
| Předmět: |
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| Zdroj: |
Obesity Science & Practice; Oct2019, Vol. 5 Issue 5, p468-478, 11p |
| Abstrakt: |
Summary: Objective: This retrospective study aimed to evaluate the impact of anti‐obesity medication (AOM) initiation, usage and duration on weight loss in a 72‐week precision obesity programme. The type of AOM, diet and exercise plan was chosen based upon an individual's biological and psychosocial needs. The 72‐week study duration allowed for a fair investigation of the downstream impact of delayed versus early AOM initiation. Methods: Participants, aged ≥18 years with body mass index ≥30 kg m−2, enrolled from 1 March 2015 to 1 April 2017, were included. Subgroups were assigned by AOM usage (users versus non‐users, early [before 8 weeks] versus delayed [after 8 weeks] AOM initiation and short [<6 months] versus long [≥6 months] AOM duration). Primary endpoints included change in baseline weight at 72 weeks and proportions achieving ≥5%, ≥10% and ≥15% weight loss. Outcomes were compared between subgroups. Results: Mean age and body mass index (N = 129) were 45.0 ± 14.0 years and 37.0 ± 6.0 kg m−2, respectively; 67% were female. At week 72, AOM users (N = 71) achieved significantly greater mean percentage reduction in baseline weight than non‐users (N = 58). On average, baseline weight decreased by 14.04 ± 6.2% in users versus 10.9 ± 6.8% in non‐users (P = 0.008); 84% and 94% of non‐user and AOM users lost >5% weight loss (P = 0.006). A higher proportion of users lost ≥15% of weight (45.1% vs. 19.0%; P < 0.001). Mean percentage reduction in weight was greater for early versus delayed starters (−17.60 ± 5.3% vs. −13.95 ± 5.5%; P = 0.024), and longer AOM usage trended towards increased weight loss. Conclusion: Early initiation of AOM may enhance weight loss. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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