| Autor: |
Endoori, S., Gulipalli, K. Ch., Bodige, S., Seelam, N. |
| Předmět: |
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| Zdroj: |
Russian Journal of Organic Chemistry; Sep2019, Vol. 55 Issue 9, p1387-1393, 7p, 4 Diagrams |
| Abstrakt: |
A novel and highly efficient synthetic approach has been developed for the synthesis of deuterium-labeled olopatadine-d6 using inexpensive and commercially available dimethyl sulfate-d6 at the stage of alkylation of primary amine intermediate. The proposed synthetic path makes it possible to avoid the use of expensive labeled reagents such as dimethyl amine-d6 used as labeled precursor in the traditional synthetic route. The structure of the obtained olapatadine-d6 has been confirmed by 1H NMR and mass spectral data. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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