Metal–DNA Coordination‐Driven Self‐Assembly: A Conceptual Methodology to Expand the Repertoire of DNA Nanobiotechnology.

Autor:	Liu, Bei, Zhang, Jingfang, Li, Lele
Předmět:	DNA nanotechnology NANOBIOTECHNOLOGY DNA BASE pairs COORDINATE covalent bond NANOSTRUCTURES
Zdroj:	Chemistry - A European Journal; 10/22/2019, Vol. 25 Issue 59, p13452-13457, 6p
Abstrakt:	The past several decades have witnessed a rapid revolution of DNA nanotechnology. DNA nanostructures are mainly synthesized with two approaches, by assembly of purely DNA‐based nanostructures through complementary base pairing or grafting DNA onto nanoparticles (NPs). Despite the progress made, developing simple and universal methods for the synthesis of DNA nanoarchitectures with specific morphologies and functionalities is still a challenge. This article introduces the reader to a new biomimetic methodology that leads to the controlled synthesis of DNA nanoarchitectures based on metal–DNA coordination chemistry and, furthermore, demonstrates the broad biomedical applications of these functional materials. In particular, we highlight the coordination‐driven 1) surface‐functionalization of NPs with DNA molecules and 2) direct self‐assembly of metal–DNA nanostructures. Finally, challenges and opportunities of this approach to develop nanobiotechnology are provided. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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