| Autor: |
Bottasso, Oscar, Besuschio, Santiago, Merlin, Victor, Morini, Julio C., Bernabo, Jorge, Falcoff, Rebeca, Falcoff, Ernesto |
| Předmět: |
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| Zdroj: |
International Journal of Dermatology; Nov1992, Vol. 31 Issue 11, p813-817, 5p |
| Abstrakt: |
We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 μg each, of recombinant interferon gamma (rIFN-γ). Except for a strong induration at the injection site, rIFN-γ produced no adverse systemic reactions and was able to promote a remarkable influx of 1-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced lysozyme reactivity. Furthermore, despite no clear-cut reduction of mycobacterial dermal burden, bacilli showed a clear increase in the granular appearance. Present findings provide a basis for further elucidation of rirN-γ as an additional tool for leprosy treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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