| Autor: |
Walczak, Anna, Przybyłowska-Sygut, Karolina, Sygut, Andrzej, Olesiejuk, Krzysztof, Cieślak, Adrianna, Mik, Michał, Dziki, Łukasz, Dziki, Adam, Majsterek, Ireneusz |
| Předmět: |
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| Zdroj: |
Polish Journal of Surgery; 2017, Vol. 89 Issue 5, p1-5, 5p |
| Abstrakt: |
The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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