| Autor: |
SAMED, NOUFEL |
| Předmět: |
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| Zdroj: |
Journal of Mines, Metals & Fuels; Jan2018, Vol. 66 Issue 1, p169-172, 4p |
| Abstrakt: |
The use of vesicles as a mode of drug delivery in the nano-size regime has gained more importance in the past two decades especially niosomes. Niosomes are vesicles which are formed by self assembly of non-ionic amphiphiles in aqueous media and has unilamellar or multilamellar structures. Glipizide is a second generation anti-diabetic drug from the sulfonylurea class also administered orally. This drug has established anti-diabetic action but it is rapid and short acting. In this study, encapsulation and sustained release of glipizide using niosomes was studied. The niosomes were prepared using Tween 80 and cholesterol by thin film hydration method. Scanning electron microscopy (SEM), drug encapsulation efficiency, and drug release studies were conducted. The entrapment efficiency was found to be around 53.97%. The drug release studies revealed a linear profile for the drug which lasted for 10-12 hours. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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