| Autor: |
Taha, Muhammad, Noreen, Tayyaba, Imran, Syahrul, Nawaz, Fasial, Chigurupati, Sridevi, Selvaraj, Manikandan, Rahim, Fazal, Hadiani Ismail, Nor, Kumar, Ashok, Mosaddik, Ashik, Alghamdi, Abdullah M., Abdulrahman nasser alqahtani, Yousif, Abdulrahman nasser alqahtani, Abdulaziz |
| Zdroj: |
Medicinal Chemistry Research; Nov2019, Vol. 28 Issue 11, p2010-2022, 13p |
| Abstrakt: |
We have synthesized nineteen (1–19) bisindolylmethane sulfonamide analogs, characterized by different spectroscopic techniques such as 1HNMR and EI-MS and tested for α-amylase inhibitory potential. All compounds showed excellent to moderate degree of α-amylase inhibitory potential with IC50 values ranging between 1.192 ± 0.51 to 3.057 ± 0.18 μM as equated with standard acarbose (IC50 values 0.83 ± 0.36 μM). Among the series, six analogs such as 1, 4, 5, 6, 10, and 14 showed potent α-amylase inhibition with IC50 values 1.747 ± 0.2, 1.208 ± 0.15, 1.192 ± 0.51, 1.858 ± 0.08, 1.358 ± 0.27 and 1.527 ± 0.17 μM, respectively, as equated with standard acarbose. The structure-activity relationship based upon different substituents on phenyl part. Molecular docking studies performed to recognize the binding interaction of the most active compounds. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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