Global Stability for a Mathematical Model of Hepatitis C: Impact of a Possible Vaccination with DAAs Therapy.

Autor: Lombardo, Salvo Danilo, Lombardo, Sebastiano
Předmět:
Zdroj: AIP Conference Proceedings; 2019, Vol. 2159 Issue 1, p030020-1-030020-7, 7p, 1 Diagram, 1 Graph
Abstrakt: Direct anti-viral agents (DAAs) allow to obtain the eradication of hepatitis C virus, but they do not prevent from possible re-infections. A vaccine can be useful to achieve this goal. Here, we study the global asymptotical stability (GAS) of the infection-free equilibrium for a recent model of hepatitis C, including immune response and alanine-aminotransferase production. Some suffcient conditions of global stability, based on the existence of a minimum positive antibody value, are obtained, thus confirming the importance of a post-therapy vaccine as an effective preventive defense to subsequent viral attacks. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index