| Autor: |
Ferron, Artur Junio Togneri, Aldini, Giancarlo, Francisqueti-Ferron, Fabiane Valentini, Silva, Carol Cristina Vágula de Almeida, Bazan, Silmeia Garcia Zanati, Garcia, Jéssica Leite, Campos, Dijon Henrique Salomé de, Ghiraldeli, Luciana, Kitawara, Koody Andre Hassemi, Altomare, Alessandra, Correa, Camila Renata, Moreto, Fernando, Ferreira, Ana Lucia A. |
| Předmět: |
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| Zdroj: |
Antioxidants; Sep2019, Vol. 8 Issue 9, p368-368, 1p |
| Abstrakt: |
The system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly divided into two experimental groups to receive either the control diet (Control, n = 20) or a high sugar-fat diet (HSF, n = 20) for 20 weeks. Once cardiac dysfunction was detected by echocardiogram in the HSF group, animals were re- divided to begin the treatment with Tomato-oleoresin or vehicle, performing four groups: Control (n = 6); (Control + Ly, n = 6); HSF (n = 6) and (HSF + Ly, n = 6). Tomato oleoresin (10 mg lycopene/kg body weight (BW) per day) was given orally every morning for a 10-week period. The analysis included nutritional and plasma biochemical parameters, systolic blood pressure, oxidative parameters in plasma, heart, and cardiac analyses in vivo and in vitro. A comparison among the groups was performed by two-way analysis of variance (ANOVA). Results: The HSF diet was able to induce obesity, insulin-resistance, cardiac dysfunction, and oxidative damage. However, the tomato-oleoresin supplementation improved insulin-resistance, cardiac remodeling, and dysfunction by improving the β-adrenergic response. It is possible to conclude that tomato-oleoresin is able to reduce the oxidative damage by improving the system's β-adrenergic response, thus recovering cardiac function. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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