| Abstrakt: |
Objective To observe the changes of the carbohydrate antigen I25 (CAI25), carbohydrate antigen I53 (CAI53), carbohydrate antigen I99 (CAI99), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) in patients with systemic lupus erythematosus (SLE) and their meanings. Methods The fasting venous serum CAI25, CAI 53, CAI 99, CEA and AFP were tested in 232 patients, and we analyzed the abnormal serum tumor markers (the test result exceeds the normal reference range). The clinical data of 232 SLE patients were collected. Person correlation analysis was used to analyze the correlation between abnormal serum tumor markers and disease activity in SLE patients. Logistic regression analysis was used to analyze the influencing factors of abnormal serum tumor markers for SLE patients. Results Seventy-five patients with serum tumor markers (AI25, CAI53, CAI99, CEA, and AFP) were abnormal in 232 SLE patients (32. 3%, 751232). Among them, the serum CAI25, CAI53, CAI99, CEA, AFP levels were found abnormal in 44 cases (58. 6%, 44175), I5 cases (20. 0%, I5/75), 25 cases (33. 3%, 25175), I4 cases (18. 7%, I4/75), and 6 cases (8. 0%, 6/75), respectively. The proportion of patients with co-infection, interstitial lung disease, and liver dysfunction was higher in the abnormal tumor markers group than in the normal tumor markers group, and the positive rate of anti-SSA antibody and anti-Sm antibody decreased (both P < 0. 05). Co-infection, interstitial lung disease, and abnormal liver function (OR = 1. 881, 1. 871, and 2. 186; 95% Cl = 1. 016-3. 48, 1. 021-3. 428, and 1. 024-4. 668, respectively; all P < 0. 05) were independent risk factors for tumor marker abnormalities in SLE patients. The abnormal incidence of serum CA125 and CA199 in SLE patients with SLEAI score > 9 points was significantly higher than that in SLE patients with SLED AI score ≤9 (P < 0. 05). Abnormal levels of serum tumor markers in SLE patients were not associated with disease activity. Conclusions Abnormal serum levels of CA125, CA153, CA199, CEA and AFP are found in SLE patients. SLE patients with abnormal serum levels of CA125, CA153, CA199, CEA, and AFP often have infection, pulmonary interstitial lesions, and abnormal liver function. The incidence of abnormal CA125 and CA199 in SLE patients is related to disease activity. [ABSTRACT FROM AUTHOR] |
