| Autor: |
Бойко, О. А., Лавренчук, Г. Й., Липська, А. І., Талько, В. В., Асмолкова, В. С. |
| Předmět: |
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| Zdroj: |
Problems of Radiation Medicine & Radiobiology; 2017, Issue 22, p172-183, 12p |
| Abstrakt: |
Objective: to investigate morphological changes in the primary thyroid cell culture of rat infants whose parents were prenatally exposed by radioisotope iodine&131. Materials and methods: obtaining and culturing of thyroid tissue primary cell cultures of newborn rats, cytological (receipt and analysis of cell cultures agents for optical microscopy), biophysical (flow&cytometry), statistics. Results. It was shown that cells in thyroid primary culture of offspring rats prenatally exposed by radioisotopes of iodine&131 signs of destructive°enerative changes were observed mostly when animals of both sexes were irra& diated. Increased number of two& and three nuclear cells and induction of ring&like cells is an evidence of signifi& cant genotoxic violation and points to the genome instability in offspring of animals exposed by radioisotope iodine&131. Conclusions. Analysis and quantitative morphological parameters of cells in thyroid primary culture of newborn rats whose parents were exposed prenatally by radioisotopes of iodine&131 showed that upon exposure to radiation thy& roid undergoes destructive changes at the cellular level and, even in the second generation of offspring, leads to disruption of its functions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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