| Autor: |
Шкарупа, В. Н., Клименко, С. В., Талько, В. В. |
| Předmět: |
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| Zdroj: |
Problems of Radiation Medicine & Radiobiology; 2016, Issue 21, p159-171, 13p |
| Abstrakt: |
Objective. Cytogenetic analysis of the effects of sodium humate in induced γ&irradiation mutagenesis in Allium&test. Materials and methods. Analysis of the root meristem cells of Allium cepa L. seeds carried by ana&telophase. Inves& tigated the effect of sodium humate (100 mg/l) on cytogenetic effects γ&irradiation (137Cs) at doses of 5, 10 and 20 Gy. Results. Antimutagenic effect of sodium humate was revealed, what allows to consider it as potential therapeutic modifier of radiation damage. Antimutagenic effect of sodium humate increased with increasing irradiation dose. Spotted differential activity of the drug with respect to various types of aberrations are most effectively reducing the frequency of radiation markers mutagenesis - chromosomal aberrations manifested in lower efficiency of long term survivors against potential changes of chromosomes compared with short&lived. Conclusions. Revealed different mechanisms for implementing antimutagenic properties of sodium humate in con& dition of γ&irradiation&induced mutagenesis in Allium&test. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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