| Autor: |
Міщук, Я. М., Серга, С. В., Коляда, О. К., Остапченко, Л. І., Демидов, С. В., Козерецька, І. А. |
| Předmět: |
|
| Zdroj: |
Problems of Radiation Medicine & Radiobiology; 2015, Issue 20, p414-419, 6p |
| Abstrakt: |
Objective. To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population. Materials and methods. We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele-specific polymerase chain reaction. Results. We identified 31 individuals (20.9%) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 individuals (78.4%), whereas genotype Pro/Pro was rare and was found in one person only (0.7%). Genotype distributions were not within Hardy-Weinberg equilibrium (χ2 = 59.7, p < 0.0001). Conclusions. Arg and Pro allele frequencies in the population of Ukraine are 60 and 40% respectively, which is significantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
