| Autor: |
Maloupazoa Siawaya, A. C., Kuissi Kamgaing, E., Minto'o Rogombe, S., Obiang, T., Moungoyi Massala, E., Magossou Mbadinga, M. J. V., Leboueny, M., Mvoundza Ndjindji, O., Mveang-Nzoghe, A., Ondo, J. P., Mintsa Ndong, A., N Essone, P., Agnandji, S. T., Kaba, M., Ategbo, S., Djoba Siawaya, J. F. |
| Předmět: |
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| Zdroj: |
Paediatrics & International Child Health; Nov2019, Vol. 39 Issue 4, p249-258, 10p, 3 Diagrams, 2 Charts, 3 Graphs |
| Abstrakt: |
Background: HIV-exposed uninfected (HEU)-infants have been shown to be particularly vulnerable to infections. In this population, disturbance of the gut micro-environment might increase their susceptibility to enteric diseases and even favour the translocation of bacteria in the bloodstream. Methods: The gastro-intestinal micro-environment was explored in 22 HEU infants and 16 HIV-unexposed (HU) infants aged 6–24 weeks. Faecal leucocytes, firmicutes (gram-positive bacteria) and gracilicutes (gram-negative bacteria) were assessed by cytology. Faecal lactoferrin and sIgA were measured by ELISA. The spectrum of micro-organisms in infants' stool was analysed by culturing. Results: HEU infants were 14 times more likely to have leucocytes in their stool than HU infants (p < 0.005). The lactoferrin level was significantly lower in HEU infants than in HU infants (p = 0.02). Potentially pathogenic bacteria such as Escherichia coli were more prevalent in HEU than in HU infants (64% vs 23.5%). Also, E. coli strains resistant to key antibiotics including co-trimoxazole, β-lactam (cephalosporins included) and tetraclines were observed in some HEU infants. Conclusion: HEU infants are more likely to present an inflamed digestive tract as highlighted by the presence of leucocytes. In addition, there is a real risk of colonisation of HEU infants' microbiota by resistant micro-organisms. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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