Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies.

Autor: Bharathi Devi, Subramaniam, Coral, Karunakaran, Gayathree, Karthikeyan, Bharathselvi, Muthuvel, Sivasankar, Shanmuganathan, Biswas, Jyotirmoy, Rishi, Pukhraj, Natarajan, Sundaram, Badrinath, Sengamedu, Angayarkanni, Narayanasamy, Bharathi Devi, Subramaniam Rajesh, Badrinath, Sengamedu Srinivasa
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Zdroj: Indian Journal of Ophthalmology; Oct2019, Vol. 67 Issue 10, p1762-1765, 4p
Abstrakt: We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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