| Autor: |
Yu, Sul Hwa, Esser, Lars, Khor, Song Yang, Senyschyn, Danielle, Veldhuis, Nicholas A., Whittaker, Michael R., Ercole, Francesca, Davis, Thomas P., Quinn, John F. |
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| Zdroj: |
Journal of Polymer Science. Part A, Polymer Chemistry; Sep2019, Vol. 57 Issue 18, p1982-1993, 12p |
| Abstrakt: |
Hydrogen sulfide (H2S), an endogenous modulator of signaling processes, has potential as a therapeutic drug or in combination drug therapies. Due to its broad biological impacts and malodorous nature, there is considerable interest in vehicles capable of delivering H2S in a controlled manner. Herein, we report postpolymerization modification of polymers incorporating glycidyl methacrylate (GMA) units to form thiol‐triggered macromolecular H2S donors. By combining this approach with polymerization‐induced self‐assembly, this methodology allows the facile preparation of polymeric nanoparticulate donors with either spherical or worm‐like morphology. The thiol‐reactive epoxide functional groups in poly(GMA) were chemically transformed into acyl‐protected perthiol groups using a three‐step procedure throughout which both morphologies remained intact. The H2S releasing properties were subsequently studied, with both spherical and worm‐like nanoparticulate donors shown to successfully release H2S in the presence of the model thiol, l‐cysteine. In addition, the donor polymers were shown to effectively increase H2S inside cells, upon exposure to biologically relevant endogenous thiol levels. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1982–1993 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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