Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics.

Autor: Schmal, Christoph, Ono, Daisuke, Myung, Jihwan, Pett, J. Patrick, Honma, Sato, Honma, Ken-Ichi, Herzel, Hanspeter, Tokuda, Isao T.
Předmět:
Zdroj: PLoS Computational Biology; 9/12/2019, Vol. 15 Issue 9, p1-25, 25p, 6 Graphs
Abstrakt: Circadian rhythms are generated by interlocked transcriptional-translational negative feedback loops (TTFLs), the molecular process implemented within a cell. The contributions, weighting and balancing between the multiple feedback loops remain debated. Dissociated, free-running dynamics in the expression of distinct clock genes has been described in recent experimental studies that applied various perturbations such as slice preparations, light pulses, jet-lag, and culture medium exchange. In this paper, we provide evidence that this “presumably transient” dissociation of circadian gene expression oscillations may occur at the single-cell level. Conceptual and detailed mechanistic mathematical modeling suggests that such dissociation is due to a weak interaction between multiple feedback loops present within a single cell. The dissociable loops provide insights into underlying mechanisms and general design principles of the molecular circadian clock. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje