| Abstrakt: |
Background: Intrauterine growth restriction (IUGR) is a complex placental vascular disease with augmented perinatal morbidity and mortality caused by various fetal, maternal as well as placental factors. This study was conducted to find any association of whichever placental histo-morphometric findings to encounter any sole placental based issues influencing fetal growth and development, which might be derived from neither fetal nor maternal basis giving consideration for any probable analogous problem for prospect pregnancies. Method: Placentas of 100 IUGR newborns (group-I) and another 100 from normal body weight newborns (group-II) were obtained between 2nd of February of 2018 and 31th of January 2019 to be studied histometrically for the number of: nuclei of syncytiotrophoblast cells, syncytial knots, chorionic terminal villi, blood vessels, and the perimeter and surface area of the villous sections, all were statistically evaluated. Results: Morphometric data confirmed that placentas of group-I had significant higher number of syncytiotrophoblasts nuclei, knots, terminal villi, blood vessels, terminal villi perimeter and cross-sectional surface area than group-II. Discussion: Encountered placental histological changes for idiopathic IUGR newborns raised suspicion it was caused by pure placental factors and could be compensation to adjust the functional requirement during placental insufficiency. Conclusions: Newborns with idiopathic IUGR could be resulted from pure placental factors which might be ascertained by histological assessment of placental tissues. [ABSTRACT FROM AUTHOR] |
