| Autor: |
Prata, Thamiris Vaz Gago, Silva, Dayane de Souza Rodrigues da, Manchiero, Caroline, Dantas, Bianca Peixoto, Mazza, Celso Carmo, Nunes, Arielle Karen da Silva, Abdala, Edson, Figueiredo, Gerusa Maria, Tengan, Fátima Mitiko, Magri, Mariana Cavalheiro |
| Předmět: |
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| Zdroj: |
Archives of Virology; Oct2019, Vol. 164 Issue 10, p2559-2563, 5p |
| Abstrakt: |
Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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